Alzheimer's Disease Biomarkers, Cognitive Reserve, and Cognition in MCI and Cognitively Unimpaired Older Adults: A structural equation model
A latent variable including blood biomarkers ptau217, ptau181, and neurofilament light chain to represent AD pathology burden predicted cognition. This adds to mounting evidence that blood biomarkers accurately predict cognitive changes in CU and MCI older adults. Delineating whether these effects were driven by MCI or high-risk CU may be a future direction with larger sample sizes.
Authors
- Jennifer Strenger
- Jordan Sergio
- Louisa I. Thompson (ORCID: https://orcid.org/0000-0002-7231-870X)
- Megan Stradtman
- Stuart Sinoff
- Jessica Alber (ORCID: https://orcid.org/0000-0002-5090-4206)
- Peter J. Snyder (ORCID: https://orcid.org/0000-0003-0555-4654)
- Ashley N. Price
- Sarah Benjamin
Institutions
- Bryn Mawr College (US)
- University of Rhode Island (US)
- Providence College (US)
- Brown University (US)
- Butler Hospital (US)
- King George Hospital (GB)
- BayCare Health System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104874
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00