Diurnal differences in cerebral microvascular blood flow and oxygen delivery across brain regions in awake mice
We reveal diurnal differences in cerebral microvascular blood flow and oxygenation, with the watershed area exhibiting a greater response to this effect. These findings underscore the potential of chronotherapeutic strategies to enhance treatment efficacy for cerebrovascular disorders.
Authors
- Qi Pian (ORCID: https://orcid.org/0000-0003-4760-8446)
- Sava Sakadžić (ORCID: https://orcid.org/0000-0001-6318-1193)
- Elga Esposito (ORCID: https://orcid.org/0000-0002-8287-2747)
- Yimeng Wu (ORCID: https://orcid.org/0000-0001-8278-8687)
- Emiri T. Mandeville (ORCID: https://orcid.org/0000-0002-7680-0923)
- Jason Porter (ORCID: https://orcid.org/0009-0002-6082-432X)
- Ken Arai (ORCID: https://orcid.org/0000-0003-1615-3258)
- Eng H. Lo (ORCID: https://orcid.org/0000-0002-9327-2915)
- Srinivasarao Allu (ORCID: https://orcid.org/0000-0002-6530-2582)
- Sergei A. Vinogradov
- Buyin Fu
- Cenk Ayata
- Hewei Cao
- Baoqiang Li
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Shenzhen Institutes of Advanced Technology (CN)
- University of Pennsylvania (US)
Publication Details
- Journal
- Neurophotonics
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1117/1.nph.13.1.015002
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00