Is Lobular Histology a Predictor of Sentinel Node Positivity in Early Breast Cancer? An Integrated Analysis of Histological Subtype and Preoperative Imaging
ILC does not independently predict SLNB positivity or nodal upstaging. Tumor size and vascular invasion remain the strongest predictors. Axillary ultrasound and MRI are reliable tools to guide de-escalation. SLNB omission in well-selected cN0 patients, including those with ILC, may be considered in tailored and selected patients.
Authors
- Luca Giuseppe Sgrò
- Valentina Elisabetta Bounous (ORCID: https://orcid.org/0000-0002-6826-4788)
- Silvia Actis (ORCID: https://orcid.org/0000-0001-8549-8669)
- Francesca Accomasso (ORCID: https://orcid.org/0000-0002-0456-874X)
- Pier Giorgio Spanu
- Elena Paradiso
- Annamaria Ferrero
- Gaia Ruggeri
Institutions
- A. O. Ordine Mauriziano di Torino (IT)
- University of Turin (IT)
Publication Details
- Journal
- Clinical Breast Cancer
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1016/j.clbc.2026.01.002
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00