Exploring brain structural effects of dopaminergic antagonism and partial agonism in antipsychotic‐naïve patients with first‐episode psychosis using normative modeling
Both partial D2R agonism and D2R antagonism appear linked to striatal volume increases; however, changes appear transient. Conversely, frontal thinning occurs over time and appears less closely linked to antipsychotic treatment. Interpreting structural brain changes in patients with psychosis require consideration of short-term pharmacological effects as well as factors related to illness progression.
Authors
- Barbora Rehák Bučková (ORCID: https://orcid.org/0000-0001-5619-3946)
- André F. Marquand (ORCID: https://orcid.org/0000-0001-5903-203X)
- Birte Yding Glenthoj (ORCID: https://orcid.org/0000-0003-3056-7262)
- Bjørn Hylsebeck Ebdrup (ORCID: https://orcid.org/0000-0002-2590-5055)
- Kirsten Borup Bojesen (ORCID: https://orcid.org/0000-0002-7996-3154)
- Mette Nielsen
- Warda Taqdees Syeda
- Anna Feveile
- Ketevan Shalikashvili
- Karen S. Ambrosen
- Jayachandra M. Raghava
Institutions
- University of Copenhagen (DK)
- Radboud University Nijmegen (NL)
- The University of Melbourne (AU)
- Mental Health Services (DK)
- Glostrup Hospital (DK)
- Rigshospitalet (DK)
- Radboud University Medical Center (NL)
- Tbilisi State Medical University (GE)
Publication Details
- Journal
- Psychiatry and Clinical Neurosciences
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1111/pcn.70017
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Lundbeckfonden
- Region Hovedstaden
- H. Lundbeck A/S