Aging Inhibits Emergency Angiogenesis and Exacerbates Neuronal Damage by Downregulating DARS2
This study suggests that aging impedes M2-like microglial polarization by downregulating DARS2 expression in microglia, thereby impairing emergency angiogenesis during acute ischemic stroke and exacerbating neuronal damage.
Authors
- Menghui Liu
- Wenchao Fu
- Tao Shen (ORCID: https://orcid.org/0009-0005-7086-8803)
- Dan Liu (ORCID: https://orcid.org/0000-0002-0545-2255)
- Rui Wang (ORCID: https://orcid.org/0000-0003-1723-4746)
- Jiayu Li (ORCID: https://orcid.org/0000-0002-2755-6549)
- Lijuan Zhang (ORCID: https://orcid.org/0000-0002-9834-1035)
- Jin Ren (ORCID: https://orcid.org/0000-0003-3707-7426)
- Xianzhang Zeng
- Yinfei Song
- Meilin Weng
- Cheng Wang
Institutions
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Chongqing Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/jir.s527147
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province