Are PTTG1 variants associated with tumor characteristics and p53/Ki-67 expression in pituitary neuroendocrine tumors
Results suggest that <i>PTTG1</i> rs3811999 may influence tumor size or growth pattern, possibly contributing to early tumorigenesis. We can hypothesize that the variant may alter gene expression or protein function, thereby predisposing to PitNETs development at an earlier stage (microadenomas). Future research should integrate molecular studies with larger genetic datasets to clarify how <i>PTTG1</i> variants contribute to PitNETs' pathophysiology.
Authors
- Rasa Liutkevičienė (ORCID: https://orcid.org/0000-0001-5395-923X)
- Jurgita Makštienė
- Alvita Vilkevičiūtė (ORCID: https://orcid.org/0000-0002-0427-5568)
- Lina Poškienė
- Monika Duseikaitė
- Birutę Žilaitienę
- Rasa Verkauskienė (ORCID: https://orcid.org/0000-0002-0108-9305)
- Martyna Juskiene
- Arimantas Tamašauskas (ORCID: https://orcid.org/0000-0002-1698-6957)
- Ieva Baikstiene
Institutions
- Lithuanian University of Health Sciences (LT)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fendo.2025.1717301
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00