Unraveling the molecular mechanisms in severe Alzheimer’s disease based on transcriptomic data using next generation knowledge discovery methods

Using NGKD methods, we identified an array of molecular pathways implicated in neuroinflammation, dysregulation of energy metabolism, and mitochondrial damage in severe AD and their association with disease progression. Our findings add to the existing knowledge on the pathophysiology of severe AD and help in the development of more effective strategies for diagnosis, therapy, and prevention.