Treatment challenges in glioblastoma: a case report
This clinical case report aimed to show the survival timeline of a glioblastoma patient who underwent surgery and received adjuvant treatments in accordance with the Stupp protocol. Starting on the day of surgery, a liquid biopsy was employed to assess the dynamic alterations in cell-free DNA (cfDNA). Upon recurrence, reoperation was conducted, and repeated radiochemotherapy was applied. This clinical case is interesting due to the extended survival time, despite the extremely aggressive nature of the medical interventions. Liquid biopsies constitute a non-invasive method of characterising circulating tumour DNA (ctDNA) and evaluating genetic and epigenetic modifications, providing considerable potential for tumour diagnosis, prognosis, and management.
Authors
- Francisco Caramelo (ORCID: https://orcid.org/0000-0002-0015-8604)
- Ana Nascimento (ORCID: https://orcid.org/0000-0001-6179-034X)
- Domingos Sanchez Roda (ORCID: https://orcid.org/0009-0000-3542-1145)
- Pedro Gonçalo Pereira Abreu (ORCID: https://orcid.org/0000-0002-3804-8427)
- Isabel M. Carreira (ORCID: https://orcid.org/0000-0001-6842-1707)
- Pedro Veiga
- Filipa Oliveira (ORCID: https://orcid.org/0000-0002-3232-905X)
- Iberê Ribeiro (ORCID: https://orcid.org/0000-0003-2430-4466)
- Joana Barbosa Melo
- Leonor Santos
Institutions
- Escola Superior de Tecnologia da Saúde de Coimbra (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Algarve Biomedical Center (PT)
- Association for Innovation and Biomedical Research on Light and Image (PT)
- University of Algarve (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fonc.2025.1651939
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Liga Portuguesa Contra o Cancro