Breast cancer recurrence and mortality among survivors of childhood cancer

Childhood cancer survivors are at high risk for developing breast cancer (BC) as a treatment-related neoplasm. Their risk for, and survival after, BC recurrence has not been characterized. In this study, female survivors had a ten-year BC recurrence risk of 14% (95% CI: 10-20%), similar to controls with sporadic BC matched by age, race, ethnicity, and disease characteristics (N = 201 pairs; P = .62). Among survivors with recurrent BC (N = 68), first BCs were largely early stage (0/I/II: 77%). Nearly half (47%) underwent bilateral mastectomies, with 81% performed before recurrence, predominantly from distant metastases. Survivors' ten-year mortality risk after BC recurrence was 89% (95% CI: 61-97%), significantly exceeding controls (40%, 95% CI: 16-57%; P = .0013), for an adjusted 2.8-fold greater risk. BC was the leading cause of death in these survivors; the ten-year cause-specific mortality probability was 67% (95% CI: 53-83%). Comprehensive investigations of BC recurrence drivers and adverse outcomes in this population are needed.

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Publication Details

Journal
JNCI Journal of the National Cancer Institute
Published
2026-01-04
DOI
https://doi.org/10.1093/jnci/djag005
Primary Topic
Childhood Cancer Survivors' Quality of Life
Type
article
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article

Breast cancer recurrence and mortality among survivors of childhood cancer

R. Nanda, Aaron McDonald, Lucie M. Turcotte, Yutaka Yasui et al.
JNCI Journal of the National Cancer Institute
Childhood Cancer Survivors' Quality of Life
article

Breast cancer recurrence and mortality among survivors of childhood cancer

R. Nanda, Aaron McDonald, Lucie M. Turcotte, Yutaka Yasui, Emily Stene, Anne Hudson Blaes, Chaya S. Moskowitz, Kevin Charles Oeffinger, Joseph P. Neglia, Tara Olive Henderson, Gregory Armstrong, Aparna Srinivasan, Hasibul Hasan, Cindy Im
article en

Abstract

Childhood cancer survivors are at high risk for developing breast cancer (BC) as a treatment-related neoplasm. Their risk for, and survival after, BC recurrence has not been characterized. In this study, female survivors had a ten-year BC recurrence risk of 14% (95% CI: 10-20%), similar to controls with sporadic BC matched by age, race, ethnicity, and disease characteristics (N = 201 pairs; P = .62). Among survivors with recurrent BC (N = 68), first BCs were largely early stage (0/I/II: 77%). Nearly half (47%) underwent bilateral mastectomies, with 81% performed before recurrence, predominantly from distant metastases. Survivors' ten-year mortality risk after BC recurrence was 89% (95% CI: 61-97%), significantly exceeding controls (40%, 95% CI: 16-57%; P = .0013), for an adjusted 2.8-fold greater risk. BC was the leading cause of death in these survivors; the ten-year cause-specific mortality probability was 67% (95% CI: 53-83%). Comprehensive investigations of BC recurrence drivers and adverse outcomes in this population are needed.

JNCI Journal of the National Cancer Institute
Northwestern University (US), University of Minnesota (US), St. Jude Children's Research Hospital (US), Memorial Sloan Kettering Cancer Center (US), Duke University (US), University of Chicago (US), Northwestern University (PH), MNGI Digestive Health (US), Northwestern Medicine (US)
Good health and well-being
Openalex Percentile: Top 96%
Childhood Cancer Survivors' Quality of Life
DOISourceOpenAlex
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