HucMSC-derived exosomes alleviate chemotherapy-induced premature ovarian insufficiency via SMURF1-mediated inhibition of ferroptosis in ovarian granulosa cells
HucMSC-Exo delivers SMURF1 to promote HO-1 degradation, which in turn suppresses Fe<sup>2+</sup> accumulation and lipid peroxidation, thereby preventing ferroptosis in GCs and ameliorating chemotherapy-induced POI.
Authors
- Yitong Shang
- Xiuying Pei
- Yu Deng (ORCID: https://orcid.org/0000-0002-3401-9434)
- Xufeng Fu (ORCID: https://orcid.org/0000-0002-2468-8079)
- Liyang Ding
- Hang Han
- Bo Xu
- Yao Hao
- Zhen Zhang
Institutions
- Ningxia Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s13287-026-04893-x
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00