Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia
These findings reveal that HF exerts anti-leukemic effects by modulating the p-eIF2α-S100A8/A9-Ca<sup>2</sup>⁺ signaling axis in AML cells. HF represents a promising therapeutic candidate for AML, particularly for patients with IDA-resistant disease.
Authors
- Jingying Zhou (ORCID: https://orcid.org/0000-0002-9740-6159)
- C Xing
- Liuzhi Shi (ORCID: https://orcid.org/0000-0001-9484-8616)
- Shixin Zhang (ORCID: https://orcid.org/0000-0003-3076-8486)
- Xi Chen (ORCID: https://orcid.org/0000-0002-6302-673X)
- Min Zhao (ORCID: https://orcid.org/0000-0002-8312-0678)
- Xuanyu Yu
- Min Li
- Bin Zhou
- Jinjun Jia
- Shirui Yu
- Chen Meng
- Shenmeng Gao
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Ningbo First Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s13020-025-01278-9
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province