Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis
Our findings not only establish brusatol as an effective agent for ameliorating psoriatic dyslipidemia, but also unveil a fundamental IL-1β-AMPK interaction that orchestrates inflammation-metabolism crosstalk.
Authors
- Kejia Lv
- Yuankuan Jiang (ORCID: https://orcid.org/0000-0001-6064-5001)
- Siyi Li (ORCID: https://orcid.org/0000-0002-9631-7971)
- Shurong Ma
- Shumeng Zhang (ORCID: https://orcid.org/0000-0002-0007-7214)
- Jingrong Lin
- Xiujie Zhang
- Renchuan Jia
- Jialin Qu
- Jinchao Yu
- Hewen Guan
Institutions
- Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s13020-025-01287-8
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province