Liquid chromatographic determination of enantiomeric purity of [11C]methyl-L-methionine and O-(2-[18F]fluoroethyl)-L-tyrosine by pre-column derivatization with o-phthaldialdehyde and N-isobutyryl-L-cysteine
The novel UPLC methods meet the Ph. Eur. monograph specifications and validation requirements. The pre-column derivatization reversed-phase (RP) chromatographic protocols are suitable for determining the enantiomeric purity of [<sup>11</sup>C]MET and [<sup>18</sup>F]FET radiopharmaceuticals and can be integrated into the quality control system.
Authors
- Viktória Csonka (ORCID: https://orcid.org/0000-0001-9288-5755)
- István Jószai (ORCID: https://orcid.org/0000-0002-1940-3390)
- Viktória Roxána Balla (ORCID: https://orcid.org/0000-0002-3952-7999)
- Viktória Forgács (ORCID: https://orcid.org/0000-0002-8586-3942)
- Zita Képes (ORCID: https://orcid.org/0000-0003-2889-8521)
- Enikő Németh
- Dezső Szikra
- György Trencsényi (ORCID: https://orcid.org/0000-0001-6456-6212)
- Dániel Szücs
Institutions
- University of Debrecen (HU)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s41181-025-00421-z
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00