Genetic Link Across Species: <i>SIX6</i> , a Major Human Glaucoma Gene, Confers Susceptibility to Glaucoma in Shiba-Inu Dogs
This study identifies rs851962234 in canine SIX6 as being significantly associated with glaucoma in Shiba-Inus, suggesting its potential role in modulating SIX6 expression and retinal ganglion cell vulnerability. These findings offer new insight into the genetic basis of canine glaucoma and highlight parallels and distinctions with human disease.
Authors
- Takuto Sakono
- Nobuyuki Kanemaki (ORCID: https://orcid.org/0000-0002-8736-6720)
- Hiroki Takahashi (ORCID: https://orcid.org/0000-0003-0528-0446)
- Nobuhisa Mizuki (ORCID: https://orcid.org/0000-0003-3738-8777)
- Yuki Mizuki (ORCID: https://orcid.org/0000-0003-3722-0659)
- Masaki Takeuchi (ORCID: https://orcid.org/0000-0002-5494-0626)
- Akira Meguro
- L.M. Endo
- Norihiro Yamada
- Jutaro Nakamura
- Maeda Aoi
- Shun Kanasashi
- Satoko Baba
- Eiichi Nomura
Institutions
- Yokohama City University Medical Center (JP)
- Azabu University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1167/iovs.67.1.5
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00