Synthesis of benzofuran derivatives using one-pot multicomponent reaction of isocyanides via ZnO-NRs

In this work ZnO-NR as reusable catalyst promoted Strecker-type reaction of 2,4-dihydroxyacetophenone, isopropenylacetylene, trimethylsilyl cyanide, primary amines and isocyanides carried out at ambient temperature under solvent-free conditions and produced amino nitriles benzofuran derivatives in high yields. Short time of reaction, high yields of product, easy separation of catalyst and products are some benefits of this procedure.