Stress-Survival Pathway Profiling Reveals MCM10 as a Candidate Biomarker of Hispanic Colorectal Cancer Disparities
The differential expression of SSP genes suggest a potential molecular contribution to CRC disparities in the Hispanic population. The essential oncogenic role of MCM10 and its axis with PPFIA1 was identified; this could lead to a new avenue for therapeutics targeting the MCM10-PPFIA1 axis, thereby, combating early-onset and advanced-stage CRC in this high-risk ethnic group.
Authors
- Urbashi Basnet
- Anamika Basu (ORCID: https://orcid.org/0000-0002-8551-0354)
- Frances A. Rangel
- Soumya Nair
- Aditi Kulkarni (ORCID: https://orcid.org/0000-0002-4886-6095)
- Angel Torres (ORCID: https://orcid.org/0009-0002-6935-8847)
- Igor C Almeida
- Md Zahirul Islam Khan
- Sourav Roy
- Taslim Al-Hilal
Institutions
- The University of Texas at El Paso (US)
- University of Utah (US)
- Copper Mountain College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-07
- DOI
- https://doi.org/10.64898/2026.01.06.698057
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- Johns Hopkins University
- National Institutes of Health
- University of Texas at El Paso
- National Institute on Minority Health and Health Disparities