HBx hijacks the miR‐19a‐3p/BAMBI/TGF‐β1 axis to impair the anti‐tumour activity of CD4 <sup>+</sup> T cells in diffuse large B‐cell lymphoma
Reduced CD4<sup>+</sup> T cell enrichment in the TME predicted poor survival in HBV<sup>+</sup> DLBCL. Down-regulation of miR-19a-3p by HBx activated the BAMBI-mediated Wnt signalling, amplifying TGF-β1 secretion to suppress anti-tumour activity of CD4⁺ T cells. The TGF-B1/TGFBR2 pair mediated the HBV<sup>+</sup> DLBCL-CD4<sup>+</sup> T cell communication. Targeting TGF-β or miR-19a-3p improved CD4<sup>+</sup> T cell immunity to suppress HBV<sup>+</sup> DLBCL progression.
Authors
- Yinghui Huang
- Zhenghao Sun
- Xiaofei Bai
- Xuecong Guo
- Jianguo Li
- Jiabang Yang
- Wangcheng ZHU
- Xudong Guo
- Jie Chen
- Xu Xu
- Jiuhong Kang
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
- Shanghai First Maternity and Infant Hospital (CN)
- Imperial College London (GB)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/ctm2.70578
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00