Monoterpenes from an aqueous extract of <i>Paeonia lactiflora</i> roots and their lipid-lowering effect

A new monoterpene, 2',6'-di-<i>O</i>-galloylalbiflorin (<b>1</b>), along with four known analogues (<b>2-5</b>), was isolated from an aqueous extract of <i>Paeonia lactiflora</i> roots. The structural elucidation of these compounds was achieved through the application of key spectroscopic approaches, specifically HR-ESIMS and 1D/2D NMR. Their inhibitory effects on intestinal lipid accumulation were evaluated at 10 μM using <i>Caenorhabditis elegans</i> as an <i>in vivo</i> screening model. Among the tested compounds, <b>3</b> and <b>5</b> displayed the most significant activity in attenuating lipid deposition.