Telomere Dynamics Influenced by Sleep, Sleep Variability and Circadian Rhythms in Older Adults With and Without Alzheimer's Risk

This study suggests that sleep, its variability and circadian rhythms may accelerate cellular aging through telomere shortening in older adults with and without AD risk factors. Our results highlight the potential value of interventions targeting sleep to reduce biological aging and vulnerability to age-related diseases.

Authors

Stéphane Rehel
Vincent de La Sayette (ORCID: https://orcid.org/0000-0003-0663-092X)
Géraldine Poisnel (ORCID: https://orcid.org/0000-0001-7943-1281)
Florence Mézenge
Géraldine Rauchs
Anne Chocat
Gaël Chetelat
Denis Vivien
Blandine Montagne
Brigitte Landeau
Perla Kaliman
Asrar Lehodey

Institutions

Universitat Oberta de Catalunya (ES)
Inserm (FR)
Centre Hospitalier Universitaire de Caen Normandie (FR)
Cyceron (FR)
Université de Caen Normandie (FR)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2025-12-01
DOI: https://doi.org/10.1002/alz70856_104780
Primary Topic: Telomeres, Telomerase, and Senescence
Type: article
Field-Weighted Citation Impact: 0.00

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article

Telomere Dynamics Influenced by Sleep, Sleep Variability and Circadian Rhythms in Older Adults With and Without Alzheimer's Risk

Stéphane Rehel, Vincent de La Sayette, Géraldine Poisnel, Florence Mézenge et al.

Dec 1, 2025

Alzheimer s & Dementia

Telomeres, Telomerase, and Senescence

article

Telomere Dynamics Influenced by Sleep, Sleep Variability and Circadian Rhythms in Older Adults With and Without Alzheimer's Risk

Stéphane Rehel, Vincent de La Sayette, Géraldine Poisnel, Florence Mézenge, Géraldine Rauchs, Anne Chocat, Gaël Chetelat, Denis Vivien, Blandine Montagne, Brigitte Landeau, Perla Kaliman, Asrar Lehodey

December 1, 2025article en

Abstract

This study suggests that sleep, its variability and circadian rhythms may accelerate cellular aging through telomere shortening in older adults with and without AD risk factors. Our results highlight the potential value of interventions targeting sleep to reduce biological aging and vulnerability to age-related diseases.

Alzheimer s & DementiaVol. 21(S2)

Universitat Oberta de Catalunya (ES), Inserm (FR), Centre Hospitalier Universitaire de Caen Normandie (FR), Cyceron (FR), Université de Caen Normandie (FR)

Quality Education

Openalex Percentile: Top 31%

Telomeres, Telomerase, and Senescence

DOI Open Access PDF OpenAlex

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Telomere Dynamics Influenced by Sleep, Sleep Variability and Circadian Rhythms in Older Adults With and Without Alzheimer's Risk — Stéphane Rehel, Vincent de La Sayette, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS