Interrupting glioblastoma malignant circuitry: plasticity traps, synaptic blockade, and myeloid reprogramming
The resilience of GBM arises from the interplay of epigenetic plasticity, neural circuit co-option, and myeloid-skewed immunosuppression. A coordinated strategy, kinome-guided targeting plus circuit disruption and myeloid reprogramming, offers a credible path to contain adaptation and improve outcomes.
Authors
- Carol Tang (ORCID: https://orcid.org/0000-0002-1835-5083)
- Nguan Soon Tan (ORCID: https://orcid.org/0000-0003-0136-7341)
- Hong Sheng Cheng (ORCID: https://orcid.org/0000-0001-9745-7872)
Institutions
- Nanyang Technological University (SG)
- National Neuroscience Institute (SG)
- National Cancer Centre Singapore (SG)
Publication Details
- Journal
- Current Opinion in Clinical Nutrition & Metabolic Care
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1097/mco.0000000000001208
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00