Genetic risk assessment of pregnancy-associated venous thromboembolism: dual utility of maternal peripheral blood in NIPT and VTE evaluation
The dual use of NIPT samples for VTE genetic assessment reduces invasive procedures and costs, offering a novel approach to optimize risk stratification, particularly for individuals with low traditional risk scores but high genetic susceptibility. These findings support integrating genetic screening into prenatal care to enable personalized prevention.
Authors
- Zhen Yang (ORCID: https://orcid.org/0000-0002-9895-4771)
- Zhe Lin (ORCID: https://orcid.org/0000-0002-3375-0970)
- X. H. Han
- Yanlin Wang (ORCID: https://orcid.org/0000-0003-2321-6309)
- Yang Li (ORCID: https://orcid.org/0000-0003-0811-2819)
- Lijian Zhao (ORCID: https://orcid.org/0009-0002-5472-0639)
- Wenqiu Xu
- Renyi Hua
- Jianguo Zhang
- Luyang Chen
Institutions
- BGI Group (China) (CN)
- International Peace Maternity & Child Health Hospital (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s12884-025-08212-9
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00