Spike antibody levels and risk of SARS-CoV-2 reinfection: a two-year cohort study in previously infected adults
Higher spike antibody levels were consistently associated with lower risk of SARS-CoV-2 reinfection, supporting their use as continuous markers of protection. Although assay-specific and without a single protective cutoff, antibody measurements may help monitor patient groups prone to poor vaccine responses-such as those receiving chemotherapy or immune-modulating drugs-and guide individualized revaccination once immune competence recovers.
Authors
- Thore Hillig (ORCID: https://orcid.org/0000-0002-2085-5183)
- Casper Roed (ORCID: https://orcid.org/0000-0001-8987-5230)
- Zitta Barrella Harboe (ORCID: https://orcid.org/0000-0001-5552-0095)
- Lisbeth K. Brandt
- Young Bae Lee Hansen (ORCID: https://orcid.org/0000-0002-8428-560X)
- Elias Frost Wiwe (ORCID: https://orcid.org/0000-0003-2695-6337)
- Thea Kølsen Fischer (ORCID: https://orcid.org/0000-0003-4812-980X)
- Mona Dates Jørgensen
- Nessrin Talouzi
Institutions
- Copenhagen University Hospital (DK)
- Nordsjællands Hospital (DK)
Publication Details
- Journal
- Vaccine
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1016/j.vaccine.2026.128194
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 32.78
Funders
- Familien Hede Nielsens Fond
- Frimodt-Heineke Fonden