Plasma Aβ40, Aβ42, Aβ42/40 ratio, tau, <i>p</i> ‐tau181, <i>p</i> ‐tau217 and NfL biomarkers to discriminate the prodromal stage of dementia along the continuum of cognitive impairment: Sex differences in the CompAS study
Our results supported the existence of sex differences in predictive association of p-tau181 and differences in the validity of p-tau217 to discriminate women and men with MCI. Sex differences in plasma concentrations of p-tau-217 and, mainly, p-tau181 may confound the interpretation of these biomarkers and reduce the validity of diagnoses when sex is not considered.
Authors
- Juan Ansede‐Bermejo (ORCID: https://orcid.org/0000-0002-0576-6131)
- María Campos‐Magdaleno (ORCID: https://orcid.org/0000-0002-1785-0736)
- Cristina Lojo‐Seoane (ORCID: https://orcid.org/0000-0002-1034-972X)
- J M Aldrey
- Juan Manuel Pías‐Peleteiro (ORCID: https://orcid.org/0000-0001-9067-7987)
- Ana Nieto‐Vieites (ORCID: https://orcid.org/0000-0002-9966-9032)
- Antônio Rozas
- Jose Luis Labandeira
- Ana Rodríguez‐Pérez (ORCID: https://orcid.org/0000-0001-6900-4171)
- Ángel Carracedo
- Águeda Rojo‐Pantoja
- Alba Felpete
- David Facal
- M. José Moreno‐Carretero
- Santiago Galdo‐Álvarez
- Montserrat Zurrón
- Mónica Lindín
- Carlos Spuch
- Fernando Díaz
Institutions
- Universidade de Santiago de Compostela (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Galicia Sur Biomedical Foundation (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- Centro de Investigación Biomédica en Red (ES)
- Fundación Pública Galega de Medicina Xenómica (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104759
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00