Endothelial ZBTB16: a molecular shield against cardiac aging
ZBTB16 preserves endothelial integrity and vascular niche homeostasis, protecting against aging-associated cardiac dysfunction. Its loss promotes EC senescence and fibrosis, whereas restoring its expression may represent a therapeutic strategy to improve cardiac function and reduce cardiovascular disease risk during aging.
Authors
- Manfred Ogris (ORCID: https://orcid.org/0000-0002-4576-6961)
- Ariane Fischer (ORCID: https://orcid.org/0000-0001-8074-3354)
- Wesley Abplanalp (ORCID: https://orcid.org/0000-0001-5996-8997)
- Susanne S. Hille (ORCID: https://orcid.org/0000-0002-9809-4636)
- Vincent Elvin Leonard
- Simone-Franziska Glaser (ORCID: https://orcid.org/0000-0002-0808-2659)
- Tarik M. Bozoglu (ORCID: https://orcid.org/0000-0002-6545-2150)
- Marek Bartkuhn (ORCID: https://orcid.org/0000-0001-6872-9082)
- Pedro Felipe Malacarne (ORCID: https://orcid.org/0000-0002-9561-5985)
- Jaya Krishnan (ORCID: https://orcid.org/0000-0002-5698-7671)
- David John
- Veronica Larcher (ORCID: https://orcid.org/0000-0002-4398-7058)
- Christian Kupatt (ORCID: https://orcid.org/0000-0002-3611-1218)
- Michail Yekelchyk (ORCID: https://orcid.org/0000-0003-4792-4131)
- A. Zeiher
- Oliver Josef Müller (ORCID: https://orcid.org/0000-0001-8223-2638)
- Kathrin A. Stilz (ORCID: https://orcid.org/0000-0001-7194-3231)
- Nivethitha Manickam
- T Braun
- Ralf P. Brandes (ORCID: https://orcid.org/0000-0002-8035-0048)
- Tessa Schmachtel
- Josefine Panthel
- Katja Schmitz (ORCID: https://orcid.org/0000-0001-9023-318X)
- Lukas Tombor (ORCID: https://orcid.org/0000-0002-5867-576X)
- Haris Kujundzic
- Stefan Günther (ORCID: https://orcid.org/0000-0003-4080-5041)
- Minh-Duc Pham
- Tara Procida-Kowalski
- Stefanie Dimmeler
- Mariano Ruz Jurado
- Haider Sami
- Julian U G Wagner
- Michael Rieger
- David Rodriguez Morales
Institutions
- Goethe University Frankfurt (DE)
- Frankfurt Institute for Advanced Studies (DE)
- TUM Klinikum (DE)
- Max Planck Institute for Heart and Lung Research (DE)
- University Hospital Schleswig-Holstein (DE)
- German Centre for Cardiovascular Research (DE)
- German Center for Lung Research (DE)
- Universities of Giessen and Marburg Lung Center (DE)
- University Hospital Frankfurt (DE)
- Cardio-Pulmonary Institute (DE)
- Frankfurt University of Applied Sciences (DE)
- Medical University of Vienna (AT)
- University of Lübeck (DE)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1093/eurheartj/ehaf1063
- Citations
- 1
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81