C-Reactive Protein for Pulmonary Tuberculosis Screening and Treatment Response Monitoring in Children
C-reactive protein (CRP) was evaluated as a biomarker for pulmonary tuberculosis (TB) diagnosis and treatment response monitoring in 292 Kenyan children. Although diagnostic sensitivity was suboptimal (35.5%-50.0%), the median CRP level decreased during TB treatment in children with confirmed (<i>P</i> = .02) or unconfirmed (<i>P</i> < .001) TB, primarily among those with baseline CRP elevation ≥5 mg/L (40% [39 of 97]).
Authors
- Jerphason Mecha (ORCID: https://orcid.org/0009-0008-6446-0395)
- V Nduba
- Wilfred Murithi (ORCID: https://orcid.org/0000-0002-4495-2957)
- Lilian N. Njagi (ORCID: https://orcid.org/0000-0002-5067-0788)
- Jaclyn N Escudero (ORCID: https://orcid.org/0000-0002-3513-774X)
- Sylvia M. LaCourse (ORCID: https://orcid.org/0000-0002-9809-5997)
- John-Stewart Grace
- L Akeyo Kijaro
- Joshua Stern (ORCID: https://orcid.org/0000-0002-5424-9421)
- Elizabeth Obimbo
- Joy Githua (ORCID: https://orcid.org/0009-0007-3295-2275)
- Jacqueline Mirera
Institutions
- University of Nairobi (KE)
- University of Washington (US)
- Kenyatta National Hospital (KE)
- Kenya Medical Research Institute (KE)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1093/ofid/ofaf816
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Washington
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases