Intraperitoneal Chemotherapy Strategies in Pancreatic Ductal Adenocarcinoma: A Systematic Review of Hyperthermic Intraperitoneal Chemotherapy, Normothermic Intraperitoneal Chemotherapy, and Pressurized Intraperitoneal Aerosol Chemotherapy
Intraperitoneal chemotherapy strategies in PDAC appear feasible with signals of meaningful clinical benefit in select settings. While CRS + HIPEC may benefit carefully selected metastatic patients, NIPEC/IP-PTX and PIPAC hold value primarily in symptom control and disease stabilization. Larger prospective trials are needed to define patient selection, optimize treatment protocols, and clarify survival benefit.
Authors
- Ahmed Abdelhakeem (ORCID: https://orcid.org/0000-0001-7186-1332)
- Nency Ganatra
- Conor O’Donnell
- Pragya Jain (ORCID: https://orcid.org/0000-0001-8139-546X)
- Hani M. Babiker (ORCID: https://orcid.org/0000-0002-9368-6296)
- Oluwatayo Adeoye (ORCID: https://orcid.org/0009-0002-3007-5292)
- Dina Elantably (ORCID: https://orcid.org/0000-0002-4706-3864)
- Saivaishnavi Kamatham
- Umair Majeed (ORCID: https://orcid.org/0000-0001-5839-9905)
Institutions
- Jacksonville College (US)
- Saint Thomas Midtown Hospital (US)
- Baptist Hospital (US)
Publication Details
- Journal
- Cancers
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3390/cancers18020182
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 0.00