Atrial fibrillation signals associated with overactive bladder drugs across JADER and FAERS: disproportionality and time-to-onset analyses
These findings are hypothesis-generating, given the limitations of SRSs, such as underreporting, missing dates, and unknown exposure-and they reflect reporting patterns rather than causal risk. They outline strata and early treatment periods that may warrant clinical attention and help prioritize pharmacovigilance and targeted hypothesis-driven evaluation in routine OAB care.
Authors
- Kiyoko Nagura
- Taro Watanabe
- Hidenori Sagara
- Shiro Watanabe
Institutions
- Yamaguchi Prefecture Central Hospital (JP)
- Sanyo-Onoda City University (JP)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fphar.2025.1700587
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science, ICT and Future Planning
- U.S. Food and Drug Administration