Sirtuin 4 Knockout Aggravates Sepsis‐Induced Acute Liver Injury by Enhancing Mitochondrial Fission and Mitophagy in Hepatocytes

Sirt4 knockout (KO) aggravates liver injury in sepsis through increasing mitochondrial fission and mitophagy, which indicates a promising direction for future clinical treatment.

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Publication Details

Journal
Mediators of Inflammation
Published
2026-01-01
DOI
https://doi.org/10.1155/mi/7600668
Primary Topic
Sirtuins and Resveratrol in Medicine
Type
article
Field-Weighted Citation Impact
0.00
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article

Sirtuin 4 Knockout Aggravates Sepsis‐Induced Acute Liver Injury by Enhancing Mitochondrial Fission and Mitophagy in Hepatocytes

An He, Na Li, Dan Ma, Shu‐Ting Chang et al.
Mediators of Inflammation
Sirtuins and Resveratrol in Medicine
article

Sirtuin 4 Knockout Aggravates Sepsis‐Induced Acute Liver Injury by Enhancing Mitochondrial Fission and Mitophagy in Hepatocytes

An He, Na Li, Dan Ma, Shu‐Ting Chang, Suxin Luo
article en

Abstract

Sirt4 knockout (KO) aggravates liver injury in sepsis through increasing mitochondrial fission and mitophagy, which indicates a promising direction for future clinical treatment.

Mediators of InflammationVol. 2026(1)
The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Chongqing Medical University (CN)
Good health and well-being
Openalex Percentile: Top 97%
Sirtuins and Resveratrol in Medicine
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