Inflammatory markers (IL-6 and CRP) in childhood and their association with brain structure and psychotic experiences in adulthood
These findings suggest that individuals who go on to develop PEs were more vulnerable to the effects of circulating CRP on grey matter volume, consistent with a possible disease-specific pathway linking inflammation to psychosis. In contrast, IL-6 was associated with smaller volume in regions of the default mode network regardless of PEs, suggesting a more general effect on brain development.
Authors
- Derek Kenton Jones (ORCID: https://orcid.org/0000-0003-4409-8049)
- Glyn Lewis (ORCID: https://orcid.org/0000-0003-0189-2744)
- G Khandaker
- Edward Palmer (ORCID: https://orcid.org/0000-0002-3548-4282)
- P Laguna
- Jack Rogers
- Kate Merritt
- C. John Evans
- Arjun Sethi
- Anthony S. David
- Rachel Upthegrove
- Abraham Reichenberg
Institutions
- Birmingham City University (GB)
- King's College London (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Birmingham and Solihull Mental Health NHS Foundation Trust (GB)
- NIHR Bristol Biomedical Research Centre (GB)
- Richmond upon Thames College (GB)
- University College London (GB)
- University of Greenwich (GB)
- Cardiff University (GB)
- University of Birmingham (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.bbi.2025.106247
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Bristol