Ningxiang pig-derived Enterococcus hirae protects against E. coli-induced gut dysbiosis and inflammation via acetate/propionate-MyD88-NF-κB axis in piglets
Token together, our results reveal that Ningxiang pig-derived E. hirae alleviates E. coli-induced gut dysbiosis and inflammation potentially through the acetate/propionate-MyD88-NF-κB axis. This work provides mechanistic insights for further exploration of probiotic and postbiotic approaches against bacterial-induced intestinal inflammation. Video Abstract.
Authors
- Hongkun Li (ORCID: https://orcid.org/0009-0002-9531-0273)
- Haibo Shen (ORCID: https://orcid.org/0000-0002-1183-6570)
- Lisu Zhang
- Ji Wang (ORCID: https://orcid.org/0000-0002-7771-5819)
- Dalin Tang
- Bie Tan
- Yulong Yin
- Meng Kang
- Yunlong Meng
- Rong Cai
- Zichen Wu
Institutions
- Jingdong (China) (CN)
- Institute of Subtropical Agriculture (CN)
- Hunan Agricultural University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s40168-025-02310-8
- Citations
- 1
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 30.02