Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis
Farrerol could directly bind and stabilize the expression of RUNX1, thereby enhancing <i>SLC7A11</i> transcription and ultimately inhibiting ferroptosis. Thus, farrerol is a potential therapeutic agent for ALI.
Authors
- T Zhang
- Zhongyong Jiang
- Dongming Wu
- X Wang
- T Liu
- X G Zhang
- Yin Qing
- Sijie Zhang (ORCID: https://orcid.org/0000-0002-7165-076X)
- Shihua Deng
- Y. Yang
- Min Yang
- Ying Xu
Institutions
- Chengdu Medical College (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1720843
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 36.44
Funders
- Chengdu Medical College
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province