Thalamic responsive neurostimulation signals and seizure semiology in pediatric patients
This study demonstrates that seizure onset EEG signals are nucleus- and semiology-specific in pediatric patients receiving thalamic RNS therapy. These findings highlight the CM nucleus's central role in seizure propagation and support individualized RNS programming based on EEG frequency signatures. While limited by sample size, this work provides early evidence that thalamic EEG biomarkers can inform more precise neuromodulation strategies for pediatric DRE.
Authors
- Carrie R. Muh (ORCID: https://orcid.org/0000-0002-3764-4163)
- Ryan Chan (ORCID: https://orcid.org/0000-0003-4590-8103)
- Paul Teng (ORCID: https://orcid.org/0000-0001-5489-5768)
- A York
- Ariel Sacknovitz (ORCID: https://orcid.org/0009-0008-6236-1190)
- Patricia E. McGoldrick (ORCID: https://orcid.org/0000-0003-3381-0635)
- Steven M. Wolf (ORCID: https://orcid.org/0000-0002-7602-3474)
- Sharon John
Institutions
- Westchester Medical Center (US)
- New York Medical College (US)
- Maria Fareri Children's Hospital (US)
- Boston Children's Health Physicians (US)
Publication Details
- Journal
- Epileptic Disorders
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1002/epd2.70170
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00