Corticosteroid Therapy and Long-Term Outcomes of Post-Infectious Inflammatory Syndrome in Non-HIV Immunosuppressed Cryptococcal Meningitis: A Multicenter Case Series
Corticosteroids were associated with improvement in neurological status and neuroinflammation in non-HIV, immunosuppressed patients with PIIRS following CM. These findings support its potential role as salvage therapy in this population and highlight the need for systematic data collection or randomized trials to better guide corticosteroid use.
Authors
- Michael C Kiritsy (ORCID: https://orcid.org/0000-0001-8364-8088)
- Robin Kimiko Avery (ORCID: https://orcid.org/0000-0001-7692-3619)
- Yuya Ito (ORCID: https://orcid.org/0000-0003-1295-4357)
- Londyn J. Robinson (ORCID: https://orcid.org/0000-0002-0961-4020)
- Julie M. Steinbrink (ORCID: https://orcid.org/0000-0003-0771-3647)
- Shmuel Shoham (ORCID: https://orcid.org/0000-0001-7276-7786)
- Seher Anjum (ORCID: https://orcid.org/0009-0007-3082-0340)
- Peter R. Williamson (ORCID: https://orcid.org/0000-0002-7953-2178)
- Omer E. Beaird (ORCID: https://orcid.org/0000-0002-1093-550X)
- Lorne W. Walker (ORCID: https://orcid.org/0000-0002-2500-0504)
- Ambar Haleem (ORCID: https://orcid.org/0000-0001-9026-7128)
- Jessica S Little (ORCID: https://orcid.org/0000-0001-8093-5647)
- Tracey-Ann Höeltermann
- Song C Ong
- Andrea Finocchi
- Ina Stephens
- Cornelius N Van Dam
Institutions
- University of Rome Tor Vergata (IT)
- Brigham and Women's Hospital (US)
- Cone Health (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- Duke University (US)
- University of Washington (US)
- Johns Hopkins Medicine (US)
- University of Alabama at Birmingham (US)
- Pediatric Nephrology of Alabama (US)
- University of Virginia Children's Hospital (US)
- Dana-Farber Cancer Institute (US)
- Bambino Gesù Children's Hospital (IT)
- National Institute of Allergy and Infectious Diseases (US)
- Wisconsin Division of Public Health (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1093/infdis/jiaf620
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00