Age‐related amyloid‐β dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: cross‐sectional trajectories and longitudinal validation
Our study developed a statistical model of age-related Aβ PET trajectories using cross-sectional data, validated with longitudinal data. NHWs had steeper trajectories of AB accumulation compared to Koreans. The results suggest differences in population-specific patterns of Aβ accumulation.
Authors
- Min Young Chun (ORCID: https://orcid.org/0000-0003-3731-6132)
- K. Kim
- Sungjoo Lee (ORCID: https://orcid.org/0000-0003-3564-4220)
- J S Kim
- Sohyun Yim (ORCID: https://orcid.org/0000-0002-9357-768X)
- Eun Hye Lee (ORCID: https://orcid.org/0000-0002-4206-6214)
- Duk Na
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Sang Won Seo
- Hee Jin Kim
- Heekyung Kang
- Suzanne E. Schindler
- Michael S. W. Weiner
Institutions
- University of California, San Francisco (US)
- Yonsei University (KR)
- Washington University in St. Louis (US)
- Severance Hospital (KR)
- Samsung Medical Center (KR)
- Yonsei University Health System (KR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104711
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00