Whole-Exome Sequencing for the Identification of Genetic Factors Implicated in Severe Bacterial Infections: A Systematic Review

Overall, included studies supported the use of WES as they successfully diagnosed inborn errors of immunity in patients with SBI. Future studies should follow strict guidelines to correctly prioritize disease-causing variants. Because of the rarity of this disease, sample sizes are often limited. Collaboration between research teams should allow for large-scale studies with robust statistical results.