When HIV pays the price: Fitness costs behind lenacapavir resistance

HIV can take several mutational pathways to become resistant to lenacapavir, each with distinct resistance and fitness profiles (Pennetzdorfer <i>et al.</i>, this issue).

Authors

Institutions

Publication Details

Journal
Science Translational Medicine
Published
2026-01-07
DOI
https://doi.org/10.1126/scitranslmed.aed6475
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

When HIV pays the price: Fitness costs behind lenacapavir resistance

Jonathan Z. Li, Manish C. Choudhary
Science Translational Medicine
HIV/AIDS drug development and treatment
article

When HIV pays the price: Fitness costs behind lenacapavir resistance

Jonathan Z. Li, Manish C. Choudhary
article en

Abstract

HIV can take several mutational pathways to become resistant to lenacapavir, each with distinct resistance and fitness profiles (Pennetzdorfer <i>et al.</i>, this issue).

Science Translational MedicineVol. 18(831)
Brigham and Women's Hospital (US)
Good health and well-being
Openalex Percentile: Top 97%
HIV/AIDS drug development and treatment
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

When HIV pays the price: Fitness costs behind lenacapavir resistance — Jonathan Z. Li, Manish C. Choudhary · Science Translational Medicine (2026) | TGRS Research Map | TGRS