Comparative Evaluation of the Prognostic Accuracy of IL-6 and Angiopoietin-2 for Early Severity Assessment in Acute Pancreatitis: A Systematic Review
IL-6 exhibits high but heterogeneous diagnostic performance (AUC 0.69-0.99), whereas Ang-2 demonstrates consistently high accuracy (AUC 0.79-0.98) across study designs. Combined evaluation of inflammatory and endothelial pathways appears to offer the most robust strategy for early prediction of persistent organ failure in acute pancreatitis.
Authors
- Olga Avdienko (ORCID: https://orcid.org/0000-0001-9122-1279)
- Kairat Shakeev
- Dmitriy Klyuyev (ORCID: https://orcid.org/0000-0003-2012-2227)
- Alina Ogizbayeva (ORCID: https://orcid.org/0000-0003-1006-1870)
- Aigul Baltabayeva
- Xenia Derevyashkina
Institutions
- Karaganda Medical University (KZ)
- Private Institution “Karaganda University of Kazpotrebsoyuz” (KZ)
Publication Details
- Journal
- Diseases
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3390/diseases14010024
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00