Impaired PD-1 expression in tumor-infiltrating senescent CD8+ T cells is reversed by PD-L1 blockade in a murine squamous cell carcinoma model
In the SCCVII model, aging impaired the antitumor immune responses, associated with early recruitment of M2-like TAMs. PD-1 expression in aged TME CD8T was impaired, but the PD-L1 blockade increased PD-1 expression, suggesting that the site of action for PD-L1 blockade differs between young and aged mice.
Authors
- Sayaka Katagiri (ORCID: https://orcid.org/0000-0002-5765-2742)
- Yi Lu (ORCID: https://orcid.org/0009-0004-4071-7943)
- Peiya Lin
- Shigenori Nagai (ORCID: https://orcid.org/0000-0002-5018-5942)
- Miyuki Azuma (ORCID: https://orcid.org/0000-0002-3529-4585)
- Chenyang Zhang (ORCID: https://orcid.org/0009-0002-5847-3575)
- Yuto Nagatomo
- Yuya Su
- Hiroyuki Harada
- Naoto Nishii
Institutions
- Tokyo Medical and Dental University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1016/j.job.2025.100730
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00