Dietary antigens drive the generation of functional cytotoxic intraepithelial lymphocytes for early defense against foodborne pathogens
Collectively, these findings demonstrate that dietary antigens rather than gut microbiota, are critical for the generation of innate-like cytotoxic IELs in the small intestine. Dietary antigen-driven TCRαβ+ CD8αβ+ IELs provide rapid and local immune protection against foodborne-pathogens, highlighting a previously underappreciated role of dietary antigens in shaping intestinal immune defense.
Authors
- Jaeu Yi (ORCID: https://orcid.org/0000-0003-4907-3924)
- J. H. Jung
- Charles D. Surh (ORCID: https://orcid.org/0000-0002-1401-3684)
- Kwang Soon Kim (ORCID: https://orcid.org/0000-0002-6250-1068)
Institutions
- Pohang University of Science and Technology (KR)
- La Jolla Institute for Immunology (US)
- Washington University in St. Louis (US)
- Institute for Basic Science (KR)
- Ajou University (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1639120
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Pohang University of Science and Technology
- Ajou University
- Institute for Basic Science