Follicle-stimulating hormone linked to cognitive decline and amyloid burden in postmenopausal women
Elevated FSH, not low E2, is linked to cognitive decline and Aβ pathology in postmenopausal women. FSH may be a key risk factor for cerebral Aβ deposition and cognitive decline in older women. Further research is needed to elucidate the mechanisms involved and explore hormonal interventions for AD.
Authors
- Hyun Kook Lim (ORCID: https://orcid.org/0000-0001-8742-3409)
- Dong Woo Kang (ORCID: https://orcid.org/0000-0003-3289-075X)
- Howard Jay Aizenstein (ORCID: https://orcid.org/0000-0003-4897-6582)
- Baek Ki-Hyun
- S. Lee (ORCID: https://orcid.org/0000-0002-9223-8512)
- Chang Uk Lee (ORCID: https://orcid.org/0000-0001-6398-7330)
- Sheng-Min Wang
- Yoo Hyun Um
- Sunghwan Kim
- Chaiho Jeong
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Pittsburgh (US)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- The Catholic University of Korea Uijeongbu St. Mary's Hospital (KR)
- The Catholic University of Korea Yeouido St. Mary's Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fnagi.2025.1697255
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Korea Creative Content Agency
- Ministry of Science and ICT, South Korea