Azilsartan as a novel anti-ferriptotic agent via the upregulation of the Nrf2/HO-1/SLC7A11/GPX4 axis and downregulation of inflammatory pathways in folic acid-induced acute kidney injury in male mice
Azilsartan confers potent protection against FA-induced AKI by activating the Nrf2/HO-1/SLC7A11/GPX4 axis, reducing lipid peroxidation, normalizing iron metabolism, and attenuating inflammation. These findings support azilsartan's potential as a repurposed therapy for ferroptosis-driven renal injury.
Authors
- Elaf Mahmood Shihab
- Saja Majeed Shareef
- Sohrab Abbas
- Khulood Majid Alsaraf
- Hayder Adnan Fawzi
- Rana Jawad Hasan
Institutions
- University of Baghdad (IQ)
- Mustansiriyah University (IQ)
- Al Mansour University College (IQ)
Publication Details
- Journal
- Toxicology Reports
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.toxrep.2026.102204
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 72.89