Fusobacterium nucleatum drives CD40-mediated dendritic cell activation and Th17/Treg imbalance to exacerbate intestinal inflammation in Crohn’s disease

This study demonstrates that <i>Fn</i> exacerbates intestinal inflammation under inflammatory conditions in CD through CD40-mediated DC activation and subsequent Th17/Treg imbalance. These findings establish a novel mechanistic link between microbial dysbiosis and immune dysregulation, identifying CD40 as a promising target for microbiota-directed immunotherapy.