Gut microbiota-dependent anti-inflammatory mechanisms of berberine in ameliorating hypertension: role of SCFAs, LPS reduction, and STAT3 signaling
Berberine exerts antihypertensive effects by regulating the gut flora-SCFAs-LPS-IL6-STAT3 axis, improving intestinal barrier function, and reducing systemic inflammation. This study provides a new mechanistic basis for berberine treatment of hypertension.
Authors
- Haitao Niu
- Dawei Yuan (ORCID: https://orcid.org/0000-0002-3283-7775)
- Zhongshan Yang (ORCID: https://orcid.org/0000-0001-8872-4027)
- Jingyi Chen
- Jinling CHEN
- X. Wang
- Jiali Yuan (ORCID: https://orcid.org/0000-0003-4741-1299)
- Yanhua Ou
- Fangwen Xu (ORCID: https://orcid.org/0000-0001-5089-7889)
- Shanshan Wang (ORCID: https://orcid.org/0000-0002-0575-6523)
- Haoming Du
- Kunran Bai
- Yuhan Chen
- Yaqian Hu
- Xin Li
Institutions
- Jinan University (CN)
- Animal Science Research Institute (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fphar.2025.1696934
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jinan University