Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activation
Mitochondrial dysfunction, reflected by elevated ccf-mtDNA, is implicated in FD pathogenesis and may be linked to inflammatory activation. ccf-mtDNA represents a promising diagnostic biomarker for FD, potentially offering an additional therapeutic target when combined with ERT.
Authors
- Yujing Yuan
- Yikang Wang (ORCID: https://orcid.org/0009-0006-0250-1097)
- Juan Huang
- ZhaoXia Wang
- Xinyu Zhang (ORCID: https://orcid.org/0000-0002-5979-244X)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5166-0736)
- Qingqing Wang (ORCID: https://orcid.org/0000-0001-8378-1057)
- Yi Zhao (ORCID: https://orcid.org/0000-0003-4065-5725)
- Xueqin Song
- Yun Yuan
- Jianwen Deng
Institutions
- Hebei Medical University (CN)
- Peking University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei Meteorological Bureau (CN)
- Beijing Institute of Neurosurgery (CN)
- Peking University First Hospital (CN)
- Hebei Seismological Bureau (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1706045
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University First Hospital
- Peking University