Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway
Our data demonstrated that MTX-mediated activation of the ERK/KEAP1 signaling pathway significantly induced ferroptosis by inhibiting the NRF2/HO-1/SLC7A11/GPX4 axis, thereby suppressing OC progression. These findings suggest that MTX is a promising candidate for OC treatment, offering a meaningful and effective therapeutic-strategy.
Authors
- Chenchen Yu
- Hongli Zhang (ORCID: https://orcid.org/0000-0002-0000-6168)
- Hongming Huang (ORCID: https://orcid.org/0000-0001-9695-4674)
- LI Xiaomin
- Xiaorong Zhou (ORCID: https://orcid.org/0000-0001-9943-3997)
- Erhao Zhang (ORCID: https://orcid.org/0000-0003-2654-6709)
- Jianan Cui (ORCID: https://orcid.org/0000-0003-4923-7685)
- Yao Zhou (ORCID: https://orcid.org/0000-0002-9482-4697)
- Yijing Su
- Liqin Xu
- Jialu Yuan
- Tingting Zhang
- Yan Zhou
- Rui Xu
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s12935-025-04019-y
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 36.44