Longitudinal tau‐PET accumulation and downstream effects in amyloid‐beta negative cognitively unimpaired individuals
A subgroup of Aβ- CU individuals show longitudinal tau accumulation across the neocortex. Preliminary results suggest an association with a tau-specific CSF biomarker and focal atrophy, which did not translate to changes in cognition. We will complement our analyses with a data-driven approach of classifying tau-accumulators.
Authors
- S Palmqvist
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Olof T. Strandberg
- Nicola Spotorno (ORCID: https://orcid.org/0000-0001-5404-8788)
- Anika Wuestefeld (ORCID: https://orcid.org/0000-0003-1779-3388)
- Danielle van Westen (ORCID: https://orcid.org/0000-0001-8649-9874)
- Oskar H. Hansson
- Laura E.M. Wisse
- Alexa Pichet Binette
- Niklas Mattsson‐Carlgren
- Ruben Smith
Institutions
- Malmö University (SE)
- Lund University (SE)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Skåne University Hospital (SE)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104826
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00