Synthesis and Study of antioxidant activity of pyrazolopyrimidins employing ZnO@Fe3O4 nanoparticles

The preparation of pyrazolo pyrimidinone derivatives were performed by using five component reactions of phthalaldehyde, cyanomethylamine, electron deficient acetylenic compounds, isocyanate, hydrazine and catalytic amounts of ZnO@Fe3O4-magnetic nanoparticles as a high performance catalyst under ultrasonic conditions at ambient temperature in aquause media at room temperature. It should be mentioned this catalyst was prepared using Spinacia oleracea water extract. In addition, for investigation of antioxidant ability radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media and easy separation of product and catalyst.