Diabetes-associated modifications in gut microbiota and tryptophan metabolism: implications for macrophage polarization and wound repair in mice
The reduction in gut Lactobacillus abundance induced by T2DM is associated with disrupted tryptophan-indole metabolism, which may impair macrophage polarization and wound healing. This study provides a systematic basis for microbiota-targeted therapies for diabetic wounds.
Authors
- Jiawei Feng
- Rong Shi (ORCID: https://orcid.org/0000-0002-6440-1263)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5166-0736)
- Mingmei Zhou
- Cheng Zhao
- Yiming Ni
- Shiyu Wang
- Min Tang
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s12866-025-04629-6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00