From Methotrexate Resistance to Biologic and Targeted Pharmacotherapy: A Decade of Phase 4 Clinical Trials Evidence in Rheumatoid Arthritis

Phase 4 evidence highlights the continued role of TNF inhibitors alongside newer biologic and targeted synthetic therapies in MTX-resistant RA. Trial heterogeneity reflects real world clinical complexity, underscoring the importance of treatment optimization, safety monitoring, and emerging precision strategies in contemporary RA management.

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Publication Details

Journal
Drug Design Development and Therapy
Published
2026-01-01
DOI
https://doi.org/10.2147/dddt.s581822
Primary Topic
Rheumatoid Arthritis Research and Therapies
Type
article
Field-Weighted Citation Impact
0.00
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article

From Methotrexate Resistance to Biologic and Targeted Pharmacotherapy: A Decade of Phase 4 Clinical Trials Evidence in Rheumatoid Arthritis

Shaker Alsharif
Drug Design Development and Therapy
Rheumatoid Arthritis Research and Therapies
article

From Methotrexate Resistance to Biologic and Targeted Pharmacotherapy: A Decade of Phase 4 Clinical Trials Evidence in Rheumatoid Arthritis

Shaker Alsharif
article en

Abstract

Phase 4 evidence highlights the continued role of TNF inhibitors alongside newer biologic and targeted synthetic therapies in MTX-resistant RA. Trial heterogeneity reflects real world clinical complexity, underscoring the importance of treatment optimization, safety monitoring, and emerging precision strategies in contemporary RA management.

Drug Design Development and TherapyVol. Volume 20
Umm al-Qura University (SA)
Good health and well-being
Openalex Percentile: Top 97%
Rheumatoid Arthritis Research and Therapies
DOIOpen Access PDFOpenAlex
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From Methotrexate Resistance to Biologic and Targeted Pharmacotherapy: A Decade of Phase 4 Clinical Trials Evidence in Rheumatoid Arthritis — Shaker Alsharif · Drug Design Development and Therapy (2026) | TGRS Research Map | TGRS