IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis
Our findings identify IL-27 signaling in keratinocytes as a pivotal regulator of skin inflammation in both psoriasis and AD. This highlights IL-27 as a promising therapeutic target for inflammatory skin diseases.
Authors
- Jiangluyi Cai
- Yingyuan Yu
- Y H Shi
- Z. H. Zhao
- Ssw Lin
- C. Guo
- Zhiyi Lan
- Xilin Zhang (ORCID: https://orcid.org/0009-0008-8351-7262)
- Zeyu Chen (ORCID: https://orcid.org/0000-0001-6393-1986)
- Qian Yu (ORCID: https://orcid.org/0000-0001-9576-2021)
- Lian Cui (ORCID: https://orcid.org/0000-0003-0997-6424)
- Nan Yang
- Jiajing Lu
- Siqi Li (ORCID: https://orcid.org/0009-0005-1421-1719)
- Tong Liu
- Yuanyuan Wang
- Jun Gu
Institutions
- Tongji University (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai Skin Disease Hospital (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s13578-025-01527-2
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00